These calculations are intended for educational use by healthcare professionals. Calculations must be re-checked and should not be used to guide patient care or clinical judgment (Disclaimer).
* This calculator is based on the average LDL-C reduction achieved in trials with a given therapy and therefore shows average results from lipid lowering therapy. Of note, trial populations usually have better adherence than in real-world practice. The results of untreated LDL-C calculation can be inflated by hyporesponse or non-adherence to therapy by the patient. Therefore, the calculator automatically gives an error when the calculated LDL-C exceeds 10 mmol/L. Levels this high are only seen in severely affected (homozygous) familial hypercholesterolemia patients.
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3. Cannon, C. P. et al. N. Engl. J. Med. 372, 2387–2397 (2015)
4. Lipinski, M. J. et al., Eur. Heart J. 37, 536–545 (2016)
5. Sabatine, M. S. et al. N. Engl. J. Med. 376, 1713–1722 (2017)
6. Schwartz, G. G. et al. N. Engl. J. Med. 379, 2097-2107 (2018)
7. Ballantyne, C. M. et al., Cardiovasc. Drugs Ther. 35, 853–864 (2021)
8. Nissen, S. E. et al. N. Engl. J. Med. 388, 1353-1364 (2023)
9. Ballantyne, C. M. et al., Eur. J. Prev. Cardiol. 27, 593–603 (2020)
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